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Lower the bar during dose escalation weeks, raise it when things settle
Sun HH, Tian F
A few things worth flagging for clinical practice: GI effects (nausea, diarrhea, vomiting) are dose-related and largely manageable with slow titration starting at 2 mg rather than jumping to 4 mg helps
The challenge lies in adapting to changing consumer needs without compromising on the indulgence factor that defines this space
cAMP elevation induced by GLP-1 can lead to its downstream protein kinase A (PKA) activation and enhanced signaling via cAMP-activated guanine nucleotide exchange factor (Epac) (Holz, 2004
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