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Despite the hype about weight loss drugs known as GLP-1s, serious questions have remained about their efficacy when patients wean off the drugs
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[7] [8] There may also be cardiovascular effects such as QT interval prolongation, tachycardia or heart failure which may result in death
However, because retatrutide exerts a more complex overall receptor load, early data indicates that its gastrointestinal side effects may be slightly more pronounced or frequent at the highest doses than those seen with standard tirzepatide protocols
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