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A drug with 28% mean weight loss can have very different commercial and clinical profiles depending on whether that mean is produced by a narrow cluster of super-responders or by broad consistent response across the enrolled population

By improving insulin sensitivity and reducing excess adipose tissue, GLP-1s may indirectly decrease estrogen-driven inflammation for some patients

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10.1186/s12891-022-05396-5 10 DengB.ZhuW.DuanY.HuY.ChenX.SongS.et al (2019)

Research into semaglutide and vision loss has expanded rapidly as physicians investigate reports of non-arteritic anterior ischemic optic neuropathy (NAION), a condition involving reduced blood flow to the optic nerve that can cause sudden, painless vision loss