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A better alternative is a verbal agreement where the client promises to contact their therapist or a responsible adult if they feel suicidal

Beetstra et al., 2005

This is the intensive period when significant weight loss occurs

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20,21 EMPA-REG OUTCOME was not designed to capture amputation risk, so there is currently no head-to-head comparison of amputation risk with empagliflozin versus canagliflozin, and such interpretation is likely not possible owing to multiple factors confounding any comparison between trials