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Optimization of a novel series of fused -homophenylalanine DPP-4 inhibitors was reported in detail by Jiang et al., leading to the development of -homophenylalanine analogs containing pyrrolidin-2-yl methyl amides (123)
The SURMOUNT-3 trial demonstrated tirzepatide produces 20.9% weight loss in women aged 50-65 over 72 weeks
Clinicians should maintain a high index of suspicion for mental health changes and distinguish between medication-related effects and other contributing factors
Retatrutide Phase 3 Results: What Patients Should Know Retatrutide gained more attention after the Phase 3 obesity trial results
That said, serious side effects with retatrutide were still rare in clinical trials
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