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Crit Rev Toxicol 1999;29(3):283-330
Importantly, there was no classic sedationsubjects maintained normal alertness when awake
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Viewed in perspective, the published body of data on NAD + dynamics in human tissues remains sparse, and the extrapolation of rodent-based data is not straightforward, underscoring the need for more clinical studies to gain deeper insights into systemic and tissue-specific NAD + metabolism
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