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However, environmental factors can increase ROS production (5)
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For example, GLP-1RAs may modulate the CD36-JNK-AP1 pathway by partially down-regulating prolyl 4-hydroxylase subunit alpha-1 (P4HA1), and then inhibit ROS production mediated by Ang II type I receptor, thereby ameliorating cardiac fibroblast proliferation and myocardial fibrosis [167, 168]
Wegovy is still covered for heart-attack and stroke risk reduction (BMI 27 or higher with established cardiovascular disease, no diabetes) and for MASH, a fatty liver disease
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