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Ablation of GPX4 in neurons results in rapid motor neuron degeneration and paralysis
Notably, animal models exposed to the fragment exhibit elevated fatty acid oxidation rates without the corresponding hyperinsulinemia or insulin resistance typically induced by intact hGH administration
13 , eabb3768 (2021)
Whatever the case, we infer that inhibiting TCA activity actually protects ER homeostasis in part because of its effects on ER ultrastructure
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