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We have confirmed that these TYR-catalyzed in-situ formed PRTOACs could effectively degrade overexpressed TYR in the melanocytes and subsequently decrease the melanin levels for alleviating skin hyperpigmentation within 48 h on a mouse model
Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease
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Gastrointestinal effects are rare but occasionally reported, including mild nausea or changes in appetite
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