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Some researchers may also recognise major branded references such as Pfizer or Hospira labelling, but Bacteriostatic Water should remain the primary term

High-performance liquid chromatography confirms 99% purity and quantifies every impurity present

Other potential adverse effects of high dose and long-term glutathione supplementation include: Lightening of hair colour: A logically expected effect since hair colour is dependent on the amount and type of melanin which may be altered by glutathione supplementation

One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

This is the reason glutathione is most often used in skin whitening treatments