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Annals of the Rheumatic Diseases, 68(7), 1119-1124
Treatment typically begins with a 2.5 mg dose for 4 weeks to improve gastrointestinal tolerability, followed by gradual dose increases every 4 weeks as tolerated, up to a maximum of 15 mg weekly
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This convenient schedule makes adherence easier compared to daily dosing, with consistent therapeutic effects throughout the week supporting continuous blood glucose regulation and weight management
Patients should be informed that gastrointestinal symptoms are dose dependent, common during treatment initiation and escalation, usually transient, influenced by the starting dose, and speed of titration ( Adjunctive dietary and behavioral measures may aid during treatment initiation and dose escalation
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