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The clinical consequence is most significant for drugs with narrow therapeutic indices where a 20 to 40% reduction in Cmax translates to subtherapeutic exposure
Different math entirely
A quarter of your plate is a sensible portion
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If you microdose retatrutide and lose the glucagon component, you might go from 24% weight loss to 15% weight loss, essentially converting your triple agonist into a less efficient version of what you could get from semaglutide alone
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