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Amongst the immunoregulatory factors, reactive oxygen species (ROS) and reactive nitrogen species (RNS), components of the oxidative stress event, are produced at abnormally high levels in IBD

NAD(+)-dependent RNA terminal 2' and 3' phosphomonoesterase activity of a subset of [PMID: 31019096] Laboratory literature summary: NAD(+)-dependent RNA terminal 2' and 3' phosphomonoesterase activity of a subset of Tpt1 enzymes

This results in sustained release, better tissue targeting, stronger mitochondrial protection, and improved redox balance

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