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Edgar, R
Yes Systematic literature search described
Assess each patients specific condition and discuss available treatment alternatives
Cisplatin-mediated ototoxicity is dose-dependent, bilaterally symmetric, progressive and irreversible, starting with high-frequency hearing loss and extending to mid/low frequencies with increasing accumulation
The pathogenesis originates from an imbalance in hepatic lipid homeostasis, where excessive triglyceride accumulation results from increased lipid influx, enhanced de novo lipogenesis, and impaired lipid export or oxidation
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