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Key biomarkers associated with cardiovascular outcomes include cytokines (IL-1, IL-6, TNF-, IL-17), acute-phase proteins (C-reactive protein, fibrinogen), matrix-degrading enzymes such as active matrix metalloproteinase-8, oxidative stress markers (myeloperoxidase, malondialdehyde), lipid mediators (lipoprotein-associated phospholipase A2), and microbial markers such as antibodies to Porphyromonas gingivalis
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