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In most cases, injection site reactions are mild and no cause for concern
Sickle Cell Disease Management includes hydroxyurea (first-line disease-modifying agent for HbSS/HbS), FDA-approved newer agents (crizanlizumab for vaso-occlusion prevention, voxelotor for hemolysis), chronic transfusion therapy for stroke prevention, and hematopoietic stem cell transplant (HSCT) as the only current curative option
JAK inhibitors (tofacitinib, upadacitinib) offer oral convenience, whereas monoclonal antibodies (influx, miikizumab) are more advantageous in terms of mucosal healing and long-term remission
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W Drge, R Breitkreutz - Glutathione and immune function - Proc Nutr Soc - 2000 Nov
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