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Using a nanoluciferase tag at the GLP-1R C-terminus, we were also able to obtain BRET measurements of GLP-1R redistribution to early, late and recycling endosomes that corroborate the TR-FRET responses
Overall, these studies underscore the intricate relationships between DPP-4, glucose regulation, obesity, and inflammation, highlighting its complexity and interactions with bone metabolism, along with its regulatory mechanisms, suggesting potential therapeutic implications [4, 32, 36]
Study participants tend to be healthier than the general patient population because exclusion criteria exclude comorbidities and older patients
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