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Pregnenolone serves as an intermediate in the biosynthesis of many steroid hormones, including progestogens, androgens, estrogens, glucocorticoids, mineralocorticoids, and dehydroepiandrosterone (DHEA) 2

Lysyl oxidase, which requires copper and initiates the covalent cross-linking of collagen and elastin, connects copper availability directly to extracellular-matrix maturation

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