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In June, Eli Lilly has announced Phase II results of its SYNERGY-NASH trial in which 54.9% of patients on its dual GLP-1/GIP receptor agonist tirzepatide 5 mg, 51.3% of patients on tirzepatide 10 mg and 51% of patients on tirzepatide 15 mg saw their fibrosis decreaseby at least one stage without their metabolic dysfunction-associated steatohepatitis (MASH) worsening
The choice of alternative depends on the severity of the reaction, the patient's weight loss goals, comorbidities, and individual risk-benefit assessment
T., & Hung, Y
Some researchers find that their response to tirzepatide diminishes after months of use, even at the maximum 15 mg dose
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