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24 GLP-1 receptors are also present in the floor of the fourth ventricle, notably the subfornical organ and the AP, areas not fully blocked from the peripheral circulation by the bloodbrain barrier

These compounds signal the gut to release GLP-1 and another fullness hormone called PYY, which together help regulate appetite and metabolism

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These findings, along with additional research , have found that people taking higher dosages of tirzepatide and people without type 2 diabetes tend to lose more weight than those on lower dosages and without the condition

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