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Its not uncommon in medicine to encounter situations where a treatment, especially one addressing a longstanding deficiency, might initially seem to exacerbate symptoms
Sztrymf B, Messika J, Bertrand F, et al
Disturbance of insulin signaling in diabetic patients might lead to the abnormal expression of Syn, damage to mitochondrial function, increase in mitochondrial oxidative stress, and down-regulation of the PI3K/AKT pathway, which in turn could promote the occurrence and development of PD (62)
E.BuseJ
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