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The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM 5-TR) describes OUD as a pattern of opioid use leading to problems or distress, where at least two of the following occurring within a 12-month period: Taking larger amounts or taking drugs over a longer period than intended
Vomiting occurs in a smaller percentage
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Some participants reported elevations in liver enzymes at higher doses, and this will be monitored closely in upcoming trials
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