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3-5 Proposed mechanisms include both intraocular pressure (IOP)lowering effects and IOP-independent effects
Safety and efficacy data comes from preclinical research and anecdotal reportsnot rigorous human studies
Old collagen breaks down before new collagen fully matures
Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
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