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Cysteine availability is the limiting factor of GSH synthesis due to the fact that GCLc Km for cysteine, around 270 M, is roughly equal to its intracellular concentration
Patorno E, Pawar A, Franklin JM, Najafzadeh M, Druaz-Luyet A, Brodovicz KG, et al
It is structurally similar to glucagon but has opposite effects, helping to lower blood glucose rather than raise it
Our strategy consists in replacing four consecutive amino acids of GLP-1 by three consecutive ureido residues by capitalizing on the structural resemblance of oligourea and -peptide helices
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