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PEDFIC 1 was a 24-week, double-blind study in children with PFIC1 or PFIC2
& DiMarchi, R
Animal research used weight-based dosing roughly in the range of 10 mcg per kg, which for a 80 kg human would be approximately 800 mcg per day, though extrapolation from rodent to human dose is not straightforward and this is not a clinical recommendation
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Zhang, J., et al
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