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Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice
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In addition, since GLP-1 is also produced locally within pancreatic islets, and its expression increases with the progress of diabetes development 22,23,24,25,26,27 , linagliptin may exert insulinotropic and glucagonostatic effects directly on the islets by elevating local GLP-1 concentrations
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