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A retrospective, population-based cohort study found that treatment with glucagon-like peptide-1 (GLP-1) receptor agonists was safe and associated with lower risks of cardiovascular or psychiatric comorbidities and lower mortality among patients with psoriasis

Berberine studies suggest more modest effects, though direct head-to-head comparisons are lacking

doi: 10.3389/fmed.2025.1633447 Received 22 May 2025 Accepted 11 August 2025 Published 29 August 2025 Volume 12 - 2025 Edited by Zili Xie, Icahn School of Medicine at Mount Sinai, United States Reviewed by Nina Fuller-Shavel, Synthesis Clinic, United Kingdom Ali Mussa, Omdurman Islamic University, Sudan Xiaoqing Cathy Cheng, Washington University in St

IGF-1 is mitogenic: it promotes cell growth and inhibits apoptosis, and epidemiological studies have linked chronically elevated IGF-1 to increased risk of several cancers, most consistently colorectal, breast, and prostate