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Microglia are initially activated to stage 1 DAM, which are characterized by a downregulation of homeostatic microglial genes including p2ry12 and cx3cr1 , and an upregulation of genes including trem2 , tyrobp and apoe

The volume of tear fluid was recorded as migration length (mm) on the Schirmers strip and no adverse events were reported during sample collection

Eyeglasses are the primary choice, while CLs are also widely employed, and surgical correction may be considered in specific cases

However, both vitamin D 2 and vitamin D 3 show similarly positive effects on their respective hydroxylated metabolites [93]