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We asked UNC Health endocrinologist Michael Porter, DO, why you may not be losing as much weight as you hoped and what to do about it
Glucose itself does not seem to directly modulate the catalytic activity of DPP-4, as shown in vitro , by incubating the enzyme with high concentrations of glucose (76)
How did they lose this weight (e.g., diet, exercise, medications)
Conclusion Looking ahead to diabetes care in 2026, the role of metformin is being reconsidered but not abandoned
Both medication classes can affect heart rate and blood pressure, necessitating careful monitoring
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