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Interventions such as GA (100 mg/kg, p.o., for 112 days), CGA (80 mg/kg, p.o., for 16 weeks), resveratrol (60 mg/kg, p.o., for 24 weeks), and pterostilbene (20 and 60 mg/kg, p.o., for 10 weeks) consistently enhanced antioxidant enzymes (e.g., glutathione peroxidase, superoxide dismutase, catalase) and alleviated oxidative stress in models like high-fat diet-fed rats, transgenic mice, and diabetic cognitive impairment [20, 23, 34, 37]

Although erythrocytes lack organelles, Ca 2+ influx occurs through several Ca 2+ -permeable channels

[28] Additional effects: anti-tumor activity (Folkmans concept), neurotransmitter modulation, and broad cytoprotective/organoprotective profile

It is essential to understand that this designation reflects absence of FDA-standard evidence , not documented evidence of harm

It also significantly reduced inflammatory markers TNF-alpha and destructive enzymes MMP-2/MMP-9