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Historical View: Early researchers described DSIP as incredibly safe. Animal studies failed to identify a lethal dose (LD50), and human trials reported no significant adverse events other than transient headaches or nausea
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The regulation of NSC proliferation, self-renewal, and differentiation is finely regulated by changes in the surrounding microenvironment, or niche, in which NSCs reside (reviewed in Hepatocyte growth factor contributes to the maintenance of self-renewal and proliferation of NSCs in SVZ, which express MET and produce HGF
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