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In clinical trials where a GLP-1 RA was added to background basal insulin, a general 20% basal insulin reduction in all patients or a 20% reduction in patients with an A1C 8.0%, the GLP-1 RA can be reasonably initiated without a reduction in the basal insulin dose for many patients
Verdict at a Glance Aleniglipron and orforglipron are the two leading oral non-peptide small molecule GLP-1 agonists, competing directly for the same market
These side effects are usually temporary and improve over time
Many people use a B-complex that includes riboflavin in order to get all of their B vitamins together
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