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Dual Agonist Unlike treatments that focus on a single hormone, tirzepatide activates both GLP-1 and GIP receptors
Last Reviewed: Q4 2025 Originally developed to treat Type 2 Diabetes, GLP-1s have since gained FDA approval for a variety of diseases, with new indications continually emerging
The concomitant RAAS activation, which increases ANG II levels, causes efferent arteriolar vasoconstriction with consequent increase in renal perfusion and glomerular hyperfiltration
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