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Struggling to lose weight on semaglutide or tirzepatide
For people with type 2 diabetes, the STEP-2 trial showed average weight loss of around 9.6% on the 2.4mg dose, roughly 64% of the result in people without diabetes 4
But lets keep in mind that these trials were not only funded by the maker of the medications but also had a lot of exclusion criteria
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For patients requiring long-term therapy, the risk of developing antibodies or resistance highlights the need for a broader repertoire of surface modifications that preserve efficacy while reducing these risks
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