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Opioids such as oxycodone, dosed at 2.5 mg as needed, and hydromorphone at 1 mg every 6 h as needed should only be used for acute pain that is severe or unresponsive to initial therapies not for more than 3 days
In this trial, 17,604 patients were enrolled to receive semaglutide 2.4 mg weekly or placebo and followed for approximately 36 months
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Obesity, insulin resistance, and chronic hyperglycaemia are all associated with increased inflammation and oxidative stress, which can negatively impact brain function
Patients should confirm they have reached their target maintenance dose and have been at that dose for at least 46 weeks before concluding that appetite suppression is inadequate
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