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While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

In the GLORY-1 trial, the most frequently reported adverse events were gastrointestinal and mostly mild to moderate in severity

I dropped 60 probably in five months, hit 70 by six months, tapered the dose, got to where I am now, which is 185

Injection timing: Some researchers find that injecting in the evening reduces daytime nausea because the initial peak occurs during sleep