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However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies
Statements Author contributions FL: Software, Supervision, Methodology, Data curation, Conceptualization, Validation, Investigation, Formal Analysis, Funding acquisition, Resources, Writing review and editing, Visualization, Project administration, Writing original draft
Such stimuli are derived from two primary sources: gravitational loading due to body mass and dynamic mechanical strains transmitted via muscle contractions
This update underscores the momentum behind retatrutide as a transformative candidate in obesity care, with Phase 3 data continuing to validate its efficacy and safety
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