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Point 1 in above link is about being under treated for B12 deficiency with neuro symptoms present

Every pound of body weight translates to about 4 pounds of force on your ankles, knees and hips when youre walking, so 10 extra pounds on your frame means 40 more pounds of pressure on your joints

doi:10.1136/jnnp.2007.133025

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Neuroprotective Properties Under Investigation The Zagreb groups 2016 review in Current Neuropharmacology described peripheral BPC-157 administration altering serotonin synthesis rates in specific brain regions, particularly nigrostriatal and other dopaminergic pathways (Tohyama, Sikiric, Diksic, 2004, Life Sciences )