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*The article has been edited to include a response from the Ryffels and Swissmedic which was received after the story was published

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By contrast, 7-hydroxymitragynine (7-OH), while also labeled a partial agonist, is highly potent at the same receptors and produces dose-dependent respiratory depression and dependence signals in animal studies

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Loss of muscle mass is a key driver of bone density decline, as it reduces the dynamic strain on the skeleton, thereby accelerating disuse signaling