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Some patients benefit from combination T4/T3 therapy, though evidence supporting superiority over levothyroxine monotherapy is limited
It is intended to guide rational re-evaluation rather than to advocate indiscriminate revival of underexplored peptide systems
Gonadotrophins inhibit the expression of insulinlike growth factor binding proteinrelated protein2 mRNA in cultured human granulosaluteal cells
Clinically validated examples of in silico and structure-based approaches contributing directly to approved therapeutics include the development of HIV protease inhibitors in the 1990sthe first drugs designed using computational structureactivity relationshipsand the more recent application of GPCR crystal structures to guide ligand optimization for receptors, including the 2-adrenoceptor and GLP-1 receptor ( These tools enable peptide systems to be evaluated with a level of mechanistic precision unavailable when many were first investigated
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