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Semaglutide increases insulin secretion and reduces glucagon release

Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals

References 1 Nature Medicine (2014)Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (preclinical)