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Ipamorelin is another peptide that stimulates the release of GH but does so without affecting other hormones, making it a targeted approach to boosting GH without impacting cortisol, prolactin, or other hormone levels

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By suppressing TLR4 dimer assembly and lipid raft clustering, NAXE mitigates neuropathic pain in CIPN mice, linking membrane microdomain organization to inflammatory sensitization

Thus, the inability to account for inhibition of IGF-2 binding to the IGF-1R is an important limitation in this study, which should be considered when assessing outcomes from human trials using IGF-1R mAbs