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However, more studies are needed to determine if chronic PE training decreases NADPH-oxidase isoforms (i.e., NOX4) activity from immune cells infiltrated in melanocytes from vitiligo patients ( Another mechanism by which chronic PE can improve ROS production in vitiligo disease is the increase of NADPH availability (a molecule with reduced concentrations in vitiligo patients) (Shajil and Begum, 2006)

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