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The main mechanism of cardioprotective effects of GLP-1R agonists against oxidative stress-induced injury in H9c2 cells (cardiomyoblasts from Rattus norvegicus) and in cardiomyocytes is related to the scavenging of reactive oxygen species, by increasing the concentrations of endogenous antioxidant defenses and inhibiting cardiomyocyte apoptosis [42]
Scientists have been attempting to solve this problem since the early 1920s, with some of the first documented efforts focused on creating an oral version of insulin
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Gum disease and infections can raise blood sugar levels, making diabetes management more difficult
There may be a role for microdosing in certain scenarios, such as when side effects are not manageable or intolerable for patients, even at the lowest introductory dose
