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observed temporal changes in ferroptosis-related molecular expression and iron accumulation in the ipsilateral cortex following TBI

TB-500 distributes evenly throughout the body via systemic circulation

Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation

950 These works indicate the therapeutic effects of PDA NPs in combating ferroptosis