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In VSMC-specific ANK knockout mice, the levels of citrate and acetyl-CoA increased significantly, which in turn promoted the acetylation of histones H3K23ac, H3K27ac, and H4K5ac, inducing the mRNA expression of pro-inflammatory factors (CCL2, IL-6, and MMP9) and the pro-inflammatory phenotype conversion of VSMCs
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And then I think about, you know, a lot of the rest of us that maybe started pretty thin and then as age came for natural reasons, you start to put on weight and if you're not really careful about it, you can be the person who's now in their 40s and has 25 extra pounds
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