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Significant weight loss can reduce systemic inflammation, improve testosterone levels, and enhance vascular health throughout the body, including the penile vasculature
10.3390/ijms22105303 21 CseC
Semaglutide is also approved for metabolic-associated steatohepatitis, a progressive form of liver disease thats closely tied to obesity
Therefore, we speculate that applying incretin-based medications in PD models can promote insulin secretion, improve peripheral and central insulin resistance, stabilize mitochondrial function, enhance energy metabolism, and exert neuroprotective effects that stabilize dopamine homeostasis (88)