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Lancet 1987;5;2:1300-4.ArticlePubMedPMC 13

In pancreatic cells, GLP-1 binds GLP-1R to promote the conversion of ATP into cytoplasmic cAMP, further activating the intracellular PKA/AMPK signaling pathway and promoting glucose-stimulated insulin secretion (GSIS) (Kahn, 2001)

Shiitake is rich in polysaccharides (primarily glucans like lentinan), dietary fibers, proteins, vitamins, essential amino acids, sterols for flavouring, and other nutrients with significant therapeutic value

Total supply cost runs $30 to $60 for a full protocol

By promoting weight loss and improving metabolic health, GLP-1s may also indirectly reduce hot flash symptoms