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The incidence of atherosclerotic cardiovascular disease or ASCVD (myocardial infarction, fatal coronary heart disease, stroke, other deaths caused by atherosclerosis) was determined at the end of the study

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However, these beneficial effects are antagonized by pro-inflammatory adipokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6), which inhibit adiponectins activity