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The mechanism involves an increase in GLUT4 transporter expression, improving glucose uptake

The increased malonyl-CoA results in inhibition of fatty acid transport into the mitochondria resulting in reduced fat oxidation and reduced production of excess acetyl-CoA

AOD-9604 is a synthetic peptide fragment (amino acids 176-191 of human growth hormone) that stimulates fat breakdown through beta-3 adrenergic receptors in adipose tissue, working peripherally on fat cells rather than centrally on hunger signals

(August 2005)

If we want to make room for these substances the FDA can help by giving these research chemicals and peptides a proper category